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Robert Buckheit, Ph.D., President and Chief Scientific Officer
Research Publications |
| 1 |
Buckheit , R.W., Jr., Bolognesi, D.P. and Weinhold, K.J. The effects of leukemosuppressive immunotherapy on bone marrow infectious cell centers in AKR mice. Virology 157:387-396, 1987. |
| 2 |
Buckheit , R.W., Jr., Kurtzberg, J., Bolognesi, D.P. and Weinhold, K.J. The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic virus producing cells from the bone marrow of leukemia-prone AKR mice. Virology 162:354-361, 1988. |
| 3 |
Buckheit , R.W., Jr., Leiberman, S.N., Bolognesi, D.P., and Weinhold, K.J. The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice. Thymus 12:143-156, 1989. |
| 4 |
Buckheit , R.W., Jr., Bolognesi, D.P., and Weinhold, K.J. The role of bone marrow and thymic elements in the initiation and spread of leukemogenic virus production in the AKR thymus. Virology 166:533-541, 1988. |
| 5 |
Buckheit , R.W., Jr. and Swanstrom, R. Characterization of an HIV-1 isolate displaying an apparent absence of virion-associated reverse transcriptase activity. AIDS Res Hum Retrov. 7:295-302, 1991. |
| 6 |
Parker, W.B., White, E.L., Shaddix, S.C., Ross, L.J., Buckheit, R.W., Jr., Germany, J.M., Secrist, J.A., III, Vince, R., and Shannon, W.M. Mechanism of inhibition of human immunodeficiency virus type I reverse transcriptase and human DNA polymerases by the 5'-triphosphates of carbovir, 3'- azido-3-deoxythymidine, 2',3'-dideoxyguanosine, and 3-deoxthymidine. J. Biological Chemistry 266:1754-1762, 1991. |
| 7 |
White, E. L., Buckheit, R. W., Ross, L. J., Germany, J. M., Andries, K., Pauwels, R., Janssen, P.A.J., Shannon, W. M. and Chirigos, M.A. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Research 16:257-266, 1991. |
| 8 |
Vickers, T., Baker, B. F., Cook, P. D., Zounes, M., Buckheit, R. W., Jr., Germany, J. and Ecker, D.J. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Research 19:3359-3368, 1991. |
| 9 |
Gustafson, K.R., Cardellina, J. H. II., McMahon, J. B., Gulakowski, R. J., Ishitoya, J., Szallasi, Z., Lewin, N. E., Blumberg, P. M., Weislow, O. S., Beutler, J. A., Buckheit, R. W., Jr., Cragg, G. M., Cox, P. A., Bader, J. P. and Boyd, M. R. A nonpromoting phorbol from the Samoan medicinal plant Homalanthus mutans inhibits cell killing by HIV-1. J. Med. Chem. 35:1978-1986. 1992. |
| 10 |
Corless, I.B., Lisker, A., and Buckheit, R.W., Jr. Decontamination of an HIV-contaminated CPR manikin. Am. J. Pub. Health. 82:1542-1543. 1992. |
| 11 |
Clanton, D. J., Moran, R. A., McMahon, J. B., Weislow, O. S., Buckheit, R. W., Jr., Hollingshead, M. G., Ciminale, V., Felber, B.K., Pavlakis, G.N. and Bader, J. P. Sulfonic acid dyes: Inhibition of the human immunodeficiency virus and mechanism of action. AIDS Res. Hum. Retrov. 5:771-781. 1992. |
| 12 |
Kashman, Y., Gustafson, K. R., Fuller, R. W., Cardellina, J. H. II, McMahon, J. B., Currens, M. J., Buckheit, R. W. Jr., Hughes, S. H., Cragg, G. M., and Boyd, M. R. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree Calophyllum lanigerum. J. Med. Chem. 35:2735-2743. 1992. |
| 13 |
Buckheit , R.W. Jr., Germany-Decker, J., Qualls-Goodwin, K., Bowdon, B.J. and Shannon, W.M. 3'-Azido-3'-deoxythymidine-induced reduction in the ability of uninfected CD4-expressing cells to participate in syncytium formation. Proc. Natl.Acad. Sci. USA. 89:8361-8365. 1992. |
| 14 |
Buckheit, R.W., Jr., White, E.L., Shannon, W.M., Guerrero, A., Pivel, J.P., Carrasco, L., Leal, J.A., and Chirigos, M.A. Significant anti-HIV activity of new modified polyanionic polymers in vitro. Immunopharmacology and Immunotoxicology 14:707-721. 1992. |
| 15 |
Swayze, E.E., Shannon, W.M., Buckheit, R.W., Wotring, L.L., Drach, J.C. and Townsend, L.B. Synthesis, antiproliferative, and antiviral evaluation of certain acyclic 6- substituted pyrrolo[2,3-D]-pyrimidine nucleoside analogs related to sangivamycin and toyocamycin. Nucleosides and Nucleotides 11:1507-1527. 1992. |
| 16 |
Comber, R.N., Reynolds, R.C., Friedrich, J.D., Manguikian, R.A., Buckheit, R.W. Jr., Truss, J.W., Shannon, W.M. and Secrist J.A. III 5,5-Disubstituted hydantoins: Syntheses and anti-HIV activity. J. Med. Chem. 35:3567-3572. 1992. |
| 17 |
Lai, M-H.T., Tang, J., Wroblewski, V., Dee, A.G., Margolin, N., Vlahos, C., Bowdon, B., Buckheit, R., Colacino, J. and Hui, K.Y. Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. J. AIDS 6:24-31. 1993 |
| 18 |
McMahon, J.B., Gulakowski, R.J., Weislow, O.S., Schultz, R.J., Narayanan, V.L., Clanton, D.J., Pedemonte, R., Wassmundt, F.W., Buckheit, R.W., Jr., Decker, W.D., White, E.L., Bader, J.P., and Boyd, M.R. Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemoth. 37:754-760. 1993. |
| 19 |
Humblet, C.C., Lunney, E.A., Buckheit, R.W., Jr., Doggett, C., Wong, R. and Antonucci, T.K. Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection. Antiviral Research 21:73-84. 1993. |
| 20 |
Kucera, L.S., Iyer, N.P., Puckett, S.H., Buckheit, R.W., Jr., Westbrook, L., Toyer, B.R., White, E.L., Germany-Decker, J.M., Shannon, W.M., Chen, R.C.-S., Nassiri, M.R., Shipman, C, Jr., Townsend L.B., and Drach, J.C. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res. Hum. Retrov. 9:307-314. 1993. |
| 21 |
Buckheit, Jr., R.W., Hollingshead, M.G., Germany-Decker, J., White, E.L. McMahon, J.B., Allen, L.B., Ross, L.J., Decker, W.D., Westbrook, L., Shannon, W.M., Weislow, O.,Bader, J.P. and Boyd, M.R. Thiazolobenzimidazole: Biological and biochemical anti-retroviral activity of a nonnucleoside reverse transcriptase inhibitor. Antiviral Research. 21:247-266. 1993. |
| 22 |
Buckheit, R.W., Jr., Germany-Decker, J., Hollingshead, M.G. Allen, L.B., Shannon, W.M., Janssen, P.A.J., and Chirigos, M.A. Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents. AIDS Res. Hum. Retrov. 9:1097-1106. 1993. |
| 23 |
Buckheit, R.W., Jr., White, E.L., Germany-Decker, J., Allen, L.B., Ross, L.J., Shannon, W. M., Janssen, P.A.J., and Chirigos, M.A. Cell based and biochemical analysis of the anti-HIV activity of combinations of AZT and analogs of TIBO. Antiviral Chemistry Chemoth. 5:35-42. 1994. |
| 24 |
Wyatt, J.R., Vickers, T.A., Roberson, J.L., Buckheit, R.W., Jr., Klimkait, T., DeBaets, E., Davis, P.W., Rayner, B., Imbach, J.L., and Ecker, D. G-quartet structure is a potent inhibitor of HIV envelope-mediated cell fusion. Proc. Nat. Acad. Sci. USA. 91:1356-1360. 1994. |
| 25 |
25. McKee, T.C., Cardellina, J.H. II, Riccio, R., Minale, L., Moran, R.A., Gulakowski, R.J., McMahon, J.B., Buckheit, R.W., Jr., Snader, K.M., and Boyd, M.R. HIV inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates. J. Med. Chem. 37:793-797. 1994. |
| 26 |
Boyd, M.R., Hallock, Y.F., Cardellina, J.H., II, Manfredi, K.P., Blunt, J.W., McMahon, J.B., Buckheit, R.W., Jr., Bringmann, G., Zagst, R., Schaffer, M., Cragg, G.M., Thomas, D.W., and Jato, J.G. Anti-HIV michellamines from Ancistrocladus korupensis, a tropical vine from the Cameroonian rainforest; isolation, stereochemistry and biological activity. J. Med. Chem. 37:1740-1745. 1994. |
| 27 |
Buckheit, R.W., Jr., Fliakas-Boltz, V., Decker, W.D., Roberson, J.L., Pyle, C.A., White, E.L., Bowdon, B.J., McMahon, J.B., Boyd, M.R., Bader, J.P., Nickell, D.G., Barth, H. and Antonucci, T.K. Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors. Antiviral Res. 25:43-56. 1994. |
| 28 |
Buckheit, R.W., Jr., Roberson, J.L., Lackman-Smith, C., Wyatt, J.R., Vickers, T.A., DeBaets, E., Davis, P.W. and Ecker, D.J. Potent and specific inhibition of HIV-envelope-mediated cell fusion and virus binding by a phosphorothioate oligonucleotide (ISIS 5320). AIDS Res Hum. Retrov. 10:1497-1506. 1994. |
| 29 |
Buckheit, R.W., Jr., Roberson, J.L., Lackman-Smith, C., Wyatt, J.R., Vickers, T.A., DeBaets, E., Davis, P.W. and Ecker, D.J. Potent and specific inhibition of HIV-envelope-mediated cell fusion and virus binding by a phosphorothioate oligonucleotide (ISIS 5320). AIDS Res Hum. Retrov. 10:1497-1506. 1994. |
| 30 |
Gustafson, K.R., Sowder, R.C., III, Henderson, L.E., Parsons, I.C., Kashman, Y., Cardellina, J.H., II, McMahon, J.B., Buckheit, R.W., Jr., Pannell, L.K. and Boyd, M.R. Circulins A and B, novel HIV-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J. Amer. Chem. Soc. 116:9337-9338. 1994 |
| 31 |
McMahon, J.B., Currens, M.J., Gulakowski, R.J., Buckheit, R.W., Jr., Lackman-Smith, C., Hallock, Y.F. and Boyd, M.R. Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by two distinct mechanisms. Antimicrob. Agents Chemother. 39:484-488. 1995. |
| 32 |
Buckheit, R.W., Jr., Fliakas-Boltz, V., Decker, W.D., Roberson, J.L., Stup, T.L., Pyle, C.A., White, E.L., McMahon, J.B., Currens, M.J., Boyd, M.R. and Bader, J.P. Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups. Antiviral Res. 26:117-132. 1995. |
| 33 |
Ecker, D.J., Wyatt, J.R., Vickers, T., Buckheit, R., Roberson, J., and Imbach, J-L. Novel guanosine quartet structure binds to the HIV envelope and inhibits envelope mediated cell fusion. Nucleosides and Nucleotides. 14: 1117-1127. 1995. |
| 34 |
Clanton, D.J., Rice, W.G., Buckheit, R.W., Jr., Terpening, S.J., Mongelli, N., Borgia, A.L. and Bader, J.P. A novel series of sulfonated and phosphonated derivatives of distamycin which inhibit the replication of HIV. Antiviral Res. 27: 335-354. 1995. |
| 35 |
Buckheit, R.W., Jr., Fliakas-Boltz, V., Yeagy-Bargo, S., Weislow, O., Mayers, D.L., Boyer, P., Hughes, S., Chu, H.-S. and Bader, J.P. Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Virology. 210: 186-193. 1995. |
| 36 |
Broom, A.D., Agrawal, V.K., Tutonda, M.G., Fain, H.D., and Buckheit, R.W., Jr. Unusual single-stranded polyribonucleotides as potent anti-HIV agents. J. Med. Chem. 38:3253-3257. 1995. |
| 37 |
Azad, R.F., Driver, V.B., Buckheit, R.W., Jr., and Anderson, K.P. Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs. Antiviral Res. 28:101-111. 1995. |
| 38 |
Rice, W.G., Buckheit, R.W., Jr., Clanton, D, Domagala, J., Gogliotti, R., Bu, M., Graham, L., Schaeffer, C.A., Turpin, J.A., Bader, J.P., Halliday, S.M., Arthur, L.O., and Henderson, L.E. Novel inhibitors of HIV-1 p7NC zinc fingers as candidates for the treatment of AIDS. Science. 270:1194-1197. 1995. |
| 39 |
Buckheit, R.W., Jr., Kinjerski, T.L., Fliakas-Boltz, V., Russell, J.D., Stup, T.L., Pallansch, L.A., Brouwer, W.G., Dao, D.C., Harrison, W.A., Schultz, R.J., Bader, J.P. and Yang, S.S. Structure-activity and cross-resistance evaluations of a series of HIV-1-specific compounds related to oxathiin carboxanilide. Antimicrob. Agents Chemother. 39:2718-2727. 1995. |
| 40 |
Ojwang, J.O., Buckheit, R.W., Jr., Pommier, Y., Mazumder, A., De Vreese, K., Este, J.A., Pallansch, L.A., Lackman-Smith, C., Wallace, T.L., De Clercq, E., McGrath, M.S. and Rando, R.F. T30177, an oligonucleotide stabilized by an intramolecular guanosine-octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 39:2426-2435. 1995. |
| 41 |
Cushman, M., Golebiewski, M., Buckheit, R.W., Jr., and Rice, W.G. Synthesis and biological evaluation of an alkenyldiarylmethane (ADAM) which acts as a novel non-nucleoside HIV-1 reverse transcriptase inhibitor. Bioorg. Med. Chem. Letters. 5:2713-2716. 1995. |
| 42 |
42. Hollingshead, M., Roberson, J., Decker, W., Buckheit, R.W., Jr., Elder, C., Malspeis, L., Mayo, J. and Grever, M. In vivo drug screening applications of HIV-infected cells cultivated within hollow fibers in two physiologic compartments of mice. Antiviral Res. 28:265-279. 1995. |
| 43 |
Yang, S.S., Fliakas-Boltz, V., Bader, J.P. and Buckheit, R.W., Jr. Characteristics of a group of nonnucleoside reverse transcriptase inhibitors with structural diversity and potent anti-human immunodeficiency virus activity. Leukemia 9(Suppl 1):S75-S85. 1995. |
| 44 |
Yang, S.S., Pattabiraman, N., Gussio, R., Pallansch, L., Buckheit, R.W., Jr., Bader, J.P. Cross-resistance analysis and molecular modeling of nonnucleoside reverse transcriptase inhibitors targeting drug-resistance mutations in the reverse transcriptase of human immunodeficiency virus. Leukemia 11 (Suppl 3): 89-92. 1997. |
| 45 |
Kozlowski, P., Buckheit, R.W., Jr. And Jackson, S. Neutralization of HIV infection by serum IgA antibodies. Adv. Exp. Med. Biol. 371:1027-1030. 1995. |
| 46 |
Turpin, J.A., Schaeffer, C.A., Bu, M., Graham, L., Buckheit, R.W., Jr., Clanton, D. and Rice, W.G. HIV-1 replication is unaffected by human secretory leukocyte protease inhibitor. Antiviral Res. 29:269-278. 1996. |
| 47 |
McMahon, J.B., Buckheit, R.W., Jr., Gulakowski, R.J., Currens, M.J., Vistica, D.T., Shoemaker, R.H., Stinson, S.F., Russell, J.D., Bader, J.P., Narayanan, V.L., Shultz, R.J., Brouwer, W.G., Felauer, E.E., and Boyd, M.R. Biological and biochemical anti-HIV activity of UC38, a new nonnucleoside reverse transcriptase inhibitor. J. Pharmacol. Exptl. Ther. 276:298-305. 1996. |
| 48 |
Cushman, M., Golebiewski, W.M., Graham, L., Turpin, J.A., Rice, W.G., Fliakas-Boltz, V. and Buckheit, R.W., Jr. Synthesis and biological evaluation of certain alkenyldiarylmethanes (ADAMs) as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 39:3217-3227. 1996. |
| 49 |
Kinjerski, T.L., Pallansch, L.A. and Buckheit, R.W., Jr. Isolation and characterization of HIV-1 isolates resistant to oxathiin carboxanilide derivatives: Evaluation of variables in the selection process. Antiviral Chem. Chemother. 7:261-269. 1996. |
| 50 |
Currens, M.J., Gulakowski, R.J., Mariner, J.M., Moran, R.A., Buckheit, R.W., Jr. Gustafson, K.R., McMahon, J.B., and Boyd, M.R. Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus. J. Pharmacol. Exptl. Ther. 279:645-651. 1996. |
| 51 |
Buckheit, R.W., Jr., Fliakas-Boltz, V., Russell, J.D., Snow, M., Pallansch, L.A., Yang, S.S., Bader, J.P., Khan, T.N., and Zanger, M. A diarylsulfone nonnucleoside reverse transcriptase inhibitor with a unique sensitivity profile to drug-resistant virus isolates. Antiviral Chem. Chemother. 7:243-252. 1996. |
| 52 |
Halliday, S.H., Lackman-Smith, C., Decker, W.D., Bader, J.B., Rice, W., Clanton, D.J. and Buckheit, R.W., Jr. Inhibition of HIV replication by the sulfonated dye resobene. Antiviral Res. 33:41-53. 1996. |
| 53 |
Buckheit, R.W., Jr. Specialized anti-HIV testing: Expediting preclinical drug development. Drug Information Journal. 31:13-22. 1997. |
| 54 |
Rice, W.G., Turpin, J.A., Schaeffer, C.A., Graham, L., Clanton, D., Buckheit, R.W., Jr., Zaharevitz, D., Summers, M.F., Wallqvist, A. and Covell, D.G. Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc-finger inhibitors. J. Med. Chem. 39:3606-3616. 1996. |
| 55 |
Kinjerski, T.L. and Buckheit, R.W., Jr. The role of genotypic heterogeneity in wild type virus populations on the selection of nonnucleoside reverse transcriptase inhibitor-resistant viruses. Antiviral Res. 33: 109-115. 1997. |
| 56 |
Gulakowski, R.J., McMahon, J.B., Buckheit, R.W., Jr., and Boyd, M.R. Biological survey of the anti-HIV activity of prostratin. Antiviral Res. 33: 87-98. 1997. |
| 57 |
Rice, W.G., Baker, D., Schaeffer, C.A., Graham, L., Bu, M., Terpening, S., Clanton, D., Schultz, R., Bader, J.P., Buckheit, R.W., Jr., and Turpin, J.A. Inhibition of multiple phases of HIV-1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins. Antimicrob. Agents Chemother. 41:419-426. 1997. |
| 58 |
Driscoll, J.S., Mayers, D.L., Bader, J.P., Weislow, O.S., Johns, D.G. and Buckheit, R.W., Jr., 2'-Fluoro-2',3'-dideoxyarabinosyladenine (F-ddA). Activity against drug resistant HIV strains and clades A-E. Antiviral Chem. Chemother. 8:107-111. 1997. |
| 59 |
Buckheit, R.W., Jr., Hollingshead, M., Stinson, S., Fliakas-Boltz, V., Pallansch, L.A., Roberson, J., Decker, W., Elder, C., Borgel, S., Bonomi, C., Shores, R., and Bader, J.P. Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor. AIDS Res. Hum. Retrov. 13:789-796. 1997. |
| 60 |
Buckheit, R.W., Jr., Snow, M.J., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D., Snow, M., Pallansch, L.A., Brouwer, W.G., and Yang, S.S. Characterization of structurally-related anti-human immunodeficiency virus UC analogs: Highly potent nonnucleoside reverse transcriptase inhibitors with efficacy against NNRTI-resistant virus isolates. Antimicrobial Agents Chemother. 41:831-837. 1997. |
| 61 |
Rice, W.G., Turpin, J.A., Huang, M., Clanton, D., Buckheit, R.W., Jr., Covell, D.G., Wallqvist, A., McDonnell, N.B., De Guzman, R.N., Summers, M.F., Zalkow, L., Bader, J.P., Haugwitz, R.D., and Sausville, E.A. Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein. Nature Medicine 3:341-345. 1997. |
| 62 |
Zembower, D.E., Liao, S., Flavin, M.T., Xu, Z-Q., Stup, T.L., Buckheit, R.W., Jr., Khilevich, A., Mar, A. and Sheinkman, A.K. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (Ring C). J. Med. Chem. 40:1005-1017. 1997. |
| 63 |
Boyd, M.R., Gustafson, K.R., McMahon, J.B., Shoemaker, R.H., O'Keefe, B.R., Mori, T., Gulakowski, R.J., Wu, L., Rivera, M.I., Laurencot, C.M., Cardellina II, J.H., Buckheit, R.W., Jr., Nara, P.L., Pannell, L.K., Sowder II, R.C. and Henderson, L.E. Discovery of cyanovirin-N, a novel HIV (human immunodeficiency virus)-inactivating protein that binds viral surface envelope glycoprotein gp120; Potential applications to microbicide development. Antimicrob. Agents Chemother. 41:1521-1530. 1997. |
| 64 |
Roth, T., Morningstar, M.L., Boyer, P.L., Hughes, S.H., Buckheit, R.W., Jr., Michejda, C.J. Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J. Med. Chem. 40:4199-4207. 1997. |
| 65 |
Tutonda, M.G., Fain, H.D., Buckheit, R.W., Jr. and Broom, A.D. The role of hydrophobic versus hydrophilic base character in the anti-HIV activity of purine-containing polyribonucleotides. J. Med. Chem. 16:173-182. 1997. |
| 66 |
Kroeger Smith, M.B., Michejda, C.J., Hughes, S.H., Boyer, P.L., Janssen, P.A.J., Andries, K., Buckheit, R.W., Jr., and Smith, R.H. Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: Implications for the mechanism of polymerase action. Protein Eng. 10:1379-1383. 1997. |
| 67 |
White, E.L., Rose, L.M., Allan, P.W., Buckheit, R.W., Jr., Shannon, W.M. and Secrist, J.A., III. Polyamine pools in human immunodeficiency virus infected cells. J. Acq. Immunodef. Syndromes and Human Retrov. 17:101-103. 1998. |
| 68 |
Cushman, M., Casimiro-Garcia, A., Hejchman, E., Ruell, J.A., Huang, M., Schaeffer, C.A., Willimson, K., Rice, W.G. and Buckheit, R.W., Jr. New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 41:2076-2089. 1998. |
| 69 |
Turpin, J.A., Buckheit, R.W., Jr., Derse, D., Hollingshead, M., Williamson, K., Palamone, C., Osterling, M.C., Hill, S.A., Graham, L., Schaeffer, C.A., Bu, M., Huang, M., Cholody, W.M., Michejda, C.J., and Rice, W.G. Inhibition of acute, latent and chronic phase HIV-1 replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription. Antimicrob. Agents Chemother. 42:487-494. 1998. |
| 70 |
Rininger, J.A., Miller, S.B., Ma, X., Chigurpati, P., Calabreses, C., Standish, L., Wells, K., Steadle-Foster, L., Buckheit, R.W., Jr. and Babish, J.G. Preliminary, open-label, safety and efficacy study of the novel kinase inhibitor andrographolide in asymptomatic human immunodeficiency virus-infected individuals. Submitted. 1999. |
| 71 |
Tutonda, M.G., Buckheit, R.W., Jr., Agrawal, V.K. and Broom, A.D. Antiviral oligo and polyribonucleotides containing selected triazol[2,3-a] purines. J. Med. Chem. 41:4958-4964. 1998. |
| 72 |
O’Keefe, B.R., Erim, T., Beutler, J.A., Cardellina, J.H. III, Gulakowski, R.J., Krepps, B.L., McMahon, J.B., Sowder, R.C. II, Johnson, D.G., Buckheit, R.W., Jr., Stup, T.L. and Boyd, M.R. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. FEBS Letter. 431:85-90. 1998. |
| 73 |
Howard, O.M.Z., Oppenheim, J.J., Hollingshead, M.G., Covey, J.M., Bigelow, J., McCormack, J.J., Buckheit, R.W., Jr., Clanton, D.J., Turpin, J.A. and Rice, W.G. Inhibition of in vitro and in vivo HIV replication by a distamycin analog that interferes with chemokine receptor function: A candidate for chemotherapeutic and microbicidal application. J. Med. Chem. 41:2184. 1998. |
| 74 |
Buckheit, R.W., Jr., Lackman-Smith, C., Snow, M.J., Halliday, S.M., Agrawal, V.K. and Broom, A.D. PMTI, a broadly active unusual single stranded polyribonucleotide, inhibits HIV replication by two distinct mechanisms. Antiviral Chem.Chemotherapy. 10:23-32. 1999. |
| 75 |
Xu, Ze-Qi, Buckheit, R.W., Jr., Stup, T.L., Flavin, M.T., Khilevich, A., Lin, L. and Zembower, D.E. In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI. Bioorg. Med. Chem. Letters. 8: 2179-2184. 1998. |
| 76 |
Buckheit, R.W., Jr., White, E.L., Fliakas-Boltz, V., Russell, J., Stup, T.L., Kinjerski, T.L., Osterling, M.C., Weigand, A. and Bader, J.P. Unique anti-human immunodeficiency virus activity of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide and dihydrocostatolide. Antimicrobial Agents Chemoth. 43:1827-1834. 1999. |
| 77 |
Buckheit, R.W., Jr., Russell, J.D., Pallansch, L.A. and Driscoll, J.S. Anti-HIV-1 Activity of 2’-fluoro-2’,3’-dideoxyarabinosyladenine (F-ddA) used in combination with other mechanistically diverse inhibitors of HIV-1 replication. Antiviral Chem.Chemotherapy. 10:115-119. 1999. |
| 78 |
Ruell, J.A., De Clerq, E., Pannecouque, C., Witvrouw, M., Stup, T.L., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Synthesis and anti-HIV activity of cosalane analogs with substituted benzoic acid rings attached to the pharmacophore through methylene and amide linkers. J.Org. Chem. 64: 5858-5866. 1999. |
| 79 |
Quan, Y., Motakis, D., Buckheit, R.W., Jr., Xu, Z.Q.,. Flavin, M.T., Parniak, M.A. and Wainberg, M.A. Sensitivity and resistance to (+)-calanolide A of wild type and mutated forms of HIV-1 reverse transcriptase. Antiviral Therapy. 4:203-209. 1999. |
| 80 |
Casimiro-Garcia, A., Micklatcher, M., Turpin, J.A., Stup, T.L., Watson, K., Buckheit, R.W., Jr. and Cushman, M. Novel modifications in the alkenyldiarylmethane (ADAM) series of nonnucleoside reverse transcriptase inhibitors. J. Med. Chem. 18: 4861-4874. 1999. |
| 81 |
Zaharevitz, D.W., Gussio, R., Weigand, A, Jalluri, R., Pattabiraman, N., Kellogg, G.E., Pallansch, L.A.,.Yang, S.S. and Buckheit, R.W., Jr. Discovery of novel HIV-1 reverse transcriptase inhibitors using a combination of 3D database searching and 3D QSAR. Med. Chem. Res. 9:551-564. 1999. |
| 82 |
Garcia, A.C., De Clerq, E., Pannecouque, C., Witvrouw, M., Stup, T.L., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Synthesis and anti-HIV activity of cosalane analogs incorporating nitrogen in the linker chain. Bioorg. Med. Chem. 8:191-200. 2000. |
| 83 |
Xu, Z-Q, Kern, E.R., Westbrook, L., Allen, L.B., Bucjkheit, R.W., Jr., Tseng, C.K-H., Jenta, T. and Flavin, M.T. Plant-derived and semi-synthetic calanolide compounds with in vitro activity against both human immunodeficiency virus type 1 and human cytomegalovirus. Antiviral Chem. Chemother. 11:23-29. 2000. |
| 84 |
Shortnacy-Fowler, A.T., Tiwari, K.N., Montgomery, J.A., Buckheit, R.W., Jr., and Secrist, J.A. Synthesis and biological activity of 2’-fluoro-D-arabinofuranosylpyrazolo[3,4-d]pyrimidine nucleosides. Helvetica Chimica Acta. 82: 2240-2245. 2000. |
| 85 |
Stoddart, C.A., Moreno, M.E., Linquist-Stepps, V.D., Bare, C., Bogan, M.R., Gobbi, A., Buckheit, R.W., Jr., Bedard, J., Rando, R.F., and McCune, J.M. Antiviral activity of dOTC (BCH-10652) against 3TC-resistant human immunodeficiency virus type 1 in SCID-hu thy/liv mice. Antimicrob. Agents Chemother. 44:783-786. 2000. |
| 86 |
Buckheit, R.W., Jr., Russell, J.D., Xu, Z-Q, and Flavin, M. Anti-HIV-1 activity of calanolides used in combination with other mechanistically diverse inhibitors of HIV-1 replication. Antiviral Chem. Chemother. 11:321-327. 2000. |
| 87 |
Santosh, K.C., DeClercq, E., Pannecouque, C., Witvrouw, M., Loftus, T.L., Turpin, J.A., Buckheit, R.W., Jr., and Cushman, M. Anti-HIV activity of a series of cosalane amino acid conjugates. Bioorg. Med. Chem. Letters 10:2505-2508. 2000. |
| 88 |
Buckheit, R.W., Jr., Watson, K., Fliakas-Boltz, V., Russell, J., Loftus, T.L., Osterling, M.C., Turpin, J.A., Pallansch, L.A., White, E.L., Lee, J-W., Lee, S-H., Oh, J-W., Kwon, H-S., Chung, S-G., and Cho, E-H. SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of HIV-1 that also inhibits HIV-2. Antimicrobial Agents and Chemother. 45:393-400. 2001. |
| 89 |
Paul, G.C., De Clercq, E., Pannecouque, C., Witvrouw, M., Loftus, T.L., Turpin, J.A., Buckheit, R.W., Jr., and Cushman, M. Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates. Bioorg. Med. Chem. Letters. 10:2149-2152. 2000. |
| 90 |
Xu, G., Loftus, T.L., Wargo, H., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Solid-phase synthesis of the alkenyldiarylmethane (ADAM) series of non-nucleoside HIV-1 reverse transcriptase inhibitors. J. Org. Chem. 66:5958-5964. 2001. |
| 91 |
Bartram, S., Halliday, S.,Ptak, R., Fletcher, T., Buckheit, R.W., Jr. and Aller, A. A high throughput method for RNA isolation using Wizard SV96 technology. Promega High Throughput Systems Application Notes 4: 1-4 2001. |
| 92 |
Casmiro-Garcia, A., DeClercq, E., Pannecouque, C., Witvrouw, M., Loftus, T.L., Turpin, J.A., Buckheit, R.W., Jr., Fanwick, P.E. and Cushman, M. Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments. Bioorg. Med. Chem. 9:2827-2841. 2001. |
| 93 |
Xu, G., Micklatcher, M., Silvestri, M.A., Hartman, T.L., Burrier, J., Osterling, M.C., Wargo, H., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 44: 4092-4113. 2001. |
| 94 |
Buckheit, R.W., Jr. Non-nucleoside reverse transcriptase inhibitors: perspectives on novel therapeutic compounds and strategies for the treatment of HIV infection. Expert Opin Investig Drugs 10:1423-1442. 2001. |
| 95 |
Santosh, K.C., Paul, G.C., DeClercq, E., Pannecouque, C., Witvrouw, M., Loftus, T.L., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. J. Med. Chem. 44: 703-714. 2001. |
| 96 |
Kannan, A., De Clercq, E., Pannecouque, C., Witvrouw, M., Hartman, T.L., Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Synthesis and anti-HIV activity of a bile acid analog of cosalane. Tetrahedron 57:9385-9391. 2001. |
| 97 |
Hyde, R.M., Buckheit, R.W., Jr. and Broom, A.D. “Senseless” antiviral polyribonucleotides: poly (1-propargylinosinic acid). Nucleosides, Nucleotides and Nucleic Acids. 21:45-54. 2002. |
| 98 |
Xu, G., Kannan, A., Hartman, T.L., Wargo, H., Watson, K., Turpin, J.A., Buckheit, R.W., Jr., Johnson, A.A., Pommier, Y. and Cushman, M. Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents. Bioorg. Med. Chem. 10: 2807-2816. 2002. |
| 99 |
Palmer, S., Margot, N., Gilbert, H., Shaw, N., Buckheit, R.W., Jr. and Miller, M. Tenofovir, adefovir and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance. AIDS Res. Hum. Retroviruses. 17:1167-1174. 2002. |
| 100 |
Xu, G., Hartman, T.L., Wargo, H., Turpin, J.A., Buckheit, R.W., Jr., and Cushman, M. Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors with non-identical aromatic rings. Bioorg. Med. Chem. 10: 283-290. 2002. |
| 101 |
Giuffre, A.C., Higgins, J., Buckheit, R.W., Jr. and North, T.W. Susceptibility of simian immunodeficiency virus to protease inhibitors. Antimicrob. Agents Chemother. In press 2003. |
| 102 |
O’Keefe, B.R., Smee, D., Turpin, J., Saucedo, C., Buckheit, R. and Boyd, M.R. The virucidal protein Cyanovirin-N displays potent anti-influenza activity mediated through interactions with viral hemagglutinin. Submitted 2003. |
| 103 |
Hyde, R.M., Broom, A.D., and Buckheit, R.W. Jr., Antiviral amphipathic oligo- and polyribonucleotides: Analog development and biological studies. J. Med. Chem. 46:1878-1885. 2003. |
| 104 |
Bokesch, H.R., O’Keefe, B.R., McKee, T.C., Pannell, L.K., Patterson, M.L., Gardella, R.S., Sowder, R.C., Turpin, J., Buckheit, R.W., Jr. and Boyd, M.R. A potent novel anti-HIV protein from the cultured cyanobacterium, Scytonema varium. Biochemistry 42: 2578-2584. 2003. |
| 105 |
O’Keefe, B.R., Smee, D.F., Turpin, J.A., Saucedo, C.J., Gustafson, K.R., Mori, T., Blakeslee, D., Buckheit, R.W., Jr. and Boyd, M.R. Potent anti-influenza activity of Cyanovirin-N and interactions with viral hemagglutinin. Antimicrob. Agents Chemother. 47:2518-2525. 2003. |
| 106 |
Buckwold, V.E., Wilson, R.J.H., Nalca, A., Beer, B., Voss, T.G., Turpin, J.A., Buckheit, R.W., Jr., Wei, J., Wenzel-Mathers, M., Walton, E., Pallansch, M., Ward, P., Wells, J., Chuvala, L., Sloane, S., Paulman, R., Russell, J., Hartman,T. and Ptak, R. Antiviral activity of hop constituents against a series of DNA and RNA viruses. Antiviral Research. 61:57-62. 2004. |
| 107 |
Chen, X., Yang, L., Zhang, N., Turpin, J.A., Buckheit, R.W., Osterling, C., Oppenheim, J.J. and Howard, O.M.Z. Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type-1. Antimicrob. Agents Chemother. 47: 2810-2816. 2003. |
| 108 |
Novikov, M.S., Ozerov, A.A., Sim, O.G. and Buckheit, R.W., Jr. Synthesis and anti-HIV-1 activity of 2-[[2-(3,5-dimethylphenoxy)ethyl]thio]pyrimidin-4(3H)-ones. Chemistry of Heterocyclic Compounds. 439:42-47. 2004. |
| 109 |
Buckheit, R.W., Jr. Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy. Expert Opin. Investig. Drugs 13: 933-958. 2004 |
| 110 |
Horvath, A., Tokes, S., Hartman, T., Watson, K., Turpin, J.A., Buckheit, R.W., Jr., Sebesteyen, Z., Szollosi, J., Benko, I., Bardos, T.J., Dunn, J.A., Toth, F.D., Fesus, L. and Aradi, J. Suligovir [(s4dU)35] inhibits HIV-1 entry by targeting CD4 and cell surface thioredoxin. Submitted. 2004. |
| 111 |
Mori, T., O’Keefe, B.R., Sowder III, R.C., Bringans, S., Gardella, R., Berg, S., Cochran, P., Turpin, J.A., Buckheit, R.W., Jr., McMahon, J.B. and Boyd, M.R. Isolation and characterization of griffithsin, a novel HIV-inactivating protein from the red algae Griffithsia sp. In press. J. Biol. Chemistry. 2005. |
| 112 |
Ozerov A.A., Novikov M.S., Gnatjuk V.P., Lobachev A.A., Buckheit R.W. Synthesis and anti-HIV-1 activity of 1-(benzyloxymethyl)-5-(arylamino)uracil derivatives methylated in side chain. Bulletin of Volgograd Scientific Centre of Russian Academy of Medical Sciences.1:26-28. 2004. |
| 113 |
Novikov M.S., Sim O.G., Ozerov A.A., Buckheit R.W. Synthesis and antiviral activity of 2-(alkylthio)-5-[2-(aryloxy)ethyl]-6-methylpyrimidine-4(3H)-ones. Bulletin of Volgograd Scientific Centre of Russian Academy of Medical Sciences. 2:30-31. 2004. |
| 114 |
Deng, B.L., Hartman, T.L., Buckheit, R.W., Jr., Pannecouque, C., DeClercq, E., Fanwick, P.E. and Cushman, M. Design and synthesis of new alkenyldiarylmethane (ADAM) HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Submitted. 2005. |
| 115 |
Horvath, A., Tokes, S., Hartman, T., Watson, K., Turpin, J.A., Buckheit, R.W., Jr., Sebesteyen, Z., Szollosi, J., Benko, I., Bardos, T.J., Dunn, J.A., Toth, F.D., Fesus, L. and Aradi, J. Suligovir [(s4dU)35] inhibits HIV-1 entry by targeting CD4 and cell surface thioredoxin. Submitted. 2004. |
| 116 |
Srivastava, P., Hara, T., Fattah, R.J., Schito, M., Hartman, T., Buckheit, R.W., Jr., Turpin, J.A., Inman, J.K., and Appella, E. Optimization of unique thioesters as antiviral agents that target HIV-1 nucleocapsid protein (NCp7). Submitted. 2004. |
| 117 |
Buckheit, R.W., Jr., Novikov, M.S. and Ozerov, A.A. Synthesis and anti-HIV activity of 1-[(aryloxy)alkyl]uracil derivatives. To be submitted. 2004. |
| 118 |
Colleluori, D.M., Tien, D., Kang, F., Pagliei, T., Kuss, R., McCormick, T., Watson, K., McFadden, K., Chaiken, I., Buckheit, R.W., Jr. and Romano, J.W. Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development. Submitted 2004. |
| 119 |
Tien, D., Schnaare, R.L., Cohl, G., Moench, T., Doncel, G., Watson, K., Buckheit, R.W., Jr., Lewis, M., Mauck, C., Callahan, M., Douville, K. and Romano, J.W. In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. To be submitted. |
| 120 |
Turpin, J.A., Loftus, T.L., Watson, K., Kwon, H-S., Lee, S-H., Lee, J-W., Kang, D-W., Chung, S-G., Cho, E-H., and Buckheit, R.W., Jr. The structure-activity relationships of 2,4 (1H, 3H)-pyrimidinedione derivatives as potent human immunodeficiency virus inhibitors. To be submitted. |
| 121 |
Palmer, S., Russell, J., Chung, S-G, Cho, E-H, and Buckheit, R.W., Jr. Activity of SJ-3366, a nonnucleoside reverse transcriptase inhibitor of HIV-1, in combination with other anti-HIV agents against wild type and SJ-3366-resistant viral isolates. To be submitted. |
| 122 |
Buckheit, R.W., Jr., Palmer, S., Fliakas-Boltz, V., Russell, J., Hartman, T.L., Watson, K., Chung, S-G and Cho, E-H. SJ-3366 rapidly selects for resistant strains of HIV-1 and HIV-2 with reduced sensitivity to virus entry and reverse transcriptase inhibition. To be submitted. |
| 123 |
Buckheit, R.W., Jr., Watson, K., Hartman, T.L., Chung, S-G., Cho, E-H, and Turpin, J.A. SJ-3366 inhibits virus entry through interaction with a post-attachment intermediate. To be submitted. |
| 124 |
Hartman, T.L., Turpin, J.A. and Buckheit, R.W., Jr. Effect of NNRTI-resistance engendering mutations on viral fitness. To be submitted. |
| 125 |
Buckheit, R.W., Jr. Resistance to anti-infective therapeutic agents. Commissioned by Expert Opin. Investig. Drugs 2005. |
| 126 |
Ptak, R.G., Loftus, T.L., Watson, K.M., Walton, E.M., Halliday, S.M., Turpin, J.A., Buckheit, R.W., Jr., Towsend, L.B. and Drach, J.C. Triciribine is a late phase inhibitor of human immunodeficiency virus type 1 assembly and release. Submitted. 2005. |
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R. Dwayne Lunsford, Ph.D., Director, Cancer Research; Manager, Bacteriology Research
Research Publications |
| 1 |
Zalacain, M., Biswas, S., Ingraham, K. A., Ambrad, J, Bryant, A., Chalker, A. F., Iordanescu, S., Fan, J., Fan, F., Lunsford, R. D. , O'Dwyer, K., Palmer, L. M., So, C., Sylvester, D., Volker, C., Warren, P., McDevitt, D., Brown, J. R., Holmes, D. J. and Burnham, M. K. R. 2003. A global approach to identify novel broad spectrum antibacterial targets among proteins of unknown function. J. Mol. Microbiol. Biotechnol. 6:109-126 |
| 2 |
Chalker, A. F., and R. D. Lunsford. 2002. Rational identification of new antibacterial drug targets which are essential for viability using a genomics-based approach. Pharmacology and Therapeutics 95:1-20. review |
| 3 |
Fan, F., R. D. Lunsford, D. Sylvester, J. Fan, H. Celesnik, S. Iordanescu, M. Rosenberg, and D. McDevitt. 2001. Regulated ectopic expression and allelic-replacement mutagenesis as a method for gene essentiality testing in Staphylococcus aureus. Plasmid 46:71-75. |
| 4 |
Throup, J. P., F. Zappacosta, R. D. Lunsford, R. S. Annan, S. A. Carr, J. T. Lonsdale, A. P. Bryant, D. McDevitt, M. Rosenberg, and M. K. R. Burnham. 2001. The srhSR gene pair from Staphylococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function. Biochemistry. 40:10392-10401. |
| 5 |
Wilding, E. I., D. Kim, A. P. Bryant, M. N., Gwynn, R. D. Lunsford, D. McDevitt, J. E. Myers, M. Rosenberg, D. Sylvester, C.V. Stauffacher, and V. W. Rodwell. 2000. Essentiality, expression, and characterization of the class II HMG-CoA reductase of Staphylococcus aureus. J. Bacteriol. 182:5147-5152. |
| 6 |
Chalker, A. F., K Ingraham, R. D. Lunsford, A. Bryant, J. Bryant, N. Wallis, J. Broskey, S. Pearson, D. Holmes. 2000. The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence. Microbiology 146:1547-1553. |
| 7 |
Chalker, A. F., A. Lupas, K. Ingraham, C. So, R. D. Lunsford, T. Li, A. Bryant, D. J. Holmes, A. Marra, S. C. Pearson, J. Ray, M. K. R. Burnham, L. M. Palmer, S. Biswas, and M. Zalacain. 2000. Genetic characterization of Gram-postive homologs of the XerCD site-specific recombinases. J. Mol. Microbiol. Biotechnol. 2:225-233. |
| 8 |
Xia, Mingming, R. D. Lunsford, D. McDevitt, and S. Iordanescu. 1999. Rapid method for the identification of essential genes in Staphylococcus aureus. Plasmid 42:144-149. |
| 9 |
Clemans, D. L., P. E. Kolenbrander, D. V. Debabov, Q. Zhang, R. D. Lunsford, H. Sakone, C. J.Whittaker, M. P. Heaton, and F. C. Neuhaus. 1999. Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects coaggregations. Infect. Immun. 67:2464-2474. |
| 10 |
Lunsford, R. D. 1998. Streptococcal transformation: essential features and applications of a natural gene exchange system. Plasmid 39:10-20. review. |
| 11 |
Lunsford, R. D. and A. G. Roble. 1997. comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence factor dependent DNA transformation in Streptococcus gordonii. J. Bacteriol 179:3122-3126. |
| 12 |
Lunsford, R. D. and J. London. 1996. Natural genetic transformation in Streptococcus gordonii: comX imparts spontaneous competence on strain Wicky. J. Bacteriol. 178:5831-5835. |
| 13 |
Lunsford, R. D., N. Nguyen, and J. London. 1996. DNA binding activities in Streptococcus gordonii: identification of a receptor-nickase and a histone-like protein. Current Microbiology 32:95-100. |
| 14 |
Lunsford, R. D. 1995. A Tn4001 delivery system for Streptococcus gordonii (Challis). Plasmid 33:153-157. |
| 15 |
Lunsford, R. D. 1995. Recovery of RNA from oral streptococci. BioTechniques 18:412-413. |
| 16 |
Anderson, R. N., R. D. Lunsford, and P. E. Kolenbrander. 1997. Determination of the transcript size and start site of the putative sca operon of Streptococcus gordonii PK488, p.657-660. In: T. Horaud, M. Sicard, A. Bouvet, and H. deMontclos (ed.), Streptococci and the host, Plenum Publishing Corp., New York, NY. |
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Todd Parsley, Ph.D., Director, Bacteriology and Molecular Biology Services
Publications/Presentations |
| 1 |
Towner, J.S., Roehl, H.H., Todd, S., Parsley, T.B., Ho, T.V., and B.L. Semler (1996). Complex formation and template recognition in poliovirus RNA replication. In S. Jameel and E.K. Wagner (eds.), Current Developments in Animal Virology, Oxford & IBH Publishing Co., New Delhi, India, and Science Publishers Inc., Lebanon, NH USA. pp. 3-22. |
| 2 |
Blair, W.S., Nguyen, J.H.C., Parsley, T.B., and B.L. Semler (1996). Mutations in the poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition and RNA binding. Virology 218: 1-13. |
| 3 |
Roehl, H.H., Parsley, T.B., Ho, T.V., and B.L. Semler (1997). Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation. J. Virol. 71: 578-585. |
| 4 |
Parsley, T.B., Towner, J.S., Blyn, L.B., Ehrenfeld, E., and B.L. Semler (1997). Poly (rC) binding protein 2 forms a ternary complex with the 5’-terminal sequences of poliovirus RNA and the viral 3CD proteinase. RNA 3: 1124-1134. |
| 5 |
Blair, W.S., Parsley, T.B., Towner, J.S., Semler, B.L., and B.R. Cullen (1998). Utilization of a novel mammalian-cell based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. RNA 4: 215-225 |
| 6 |
Parsley, T.B., Cornell, C.T., and B.L. Semler (1999). Modulation of the RNA binding and protein processing activities of poliovirus polypeptide 3CD by the viral RNA polymerase domain. J. Biol. Chem. 274: 12867-12876. |
| 7 |
Nuss, D.N., Chen, B., Geletka, L.M., Parsley, T.B., and N. Suzuki (2001). Engineering Hypoviruses for Fundamental and Practical Applications. In S. Tavantis (ed.) dsRNA Genetic Elements: Applications in Agriculture, Forestry, and Medicine. CRC Press LLC, Boca Raton, FL USA. |
| 8 |
Parsley, T.B., Chen, B., Geletka, L.M., and D.L. Nuss (2002). Differential activation of cellular signaling pathways by mild and severe hypovirus strains. Eukaryotic Cell. 1:401-413. |
| 9 |
Walter, B.L., Parsley, T.B., Ehrenfeld, E., and B.L. Semler (2002). Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J. Virol. 76:12008-12022. |
| 10 |
Parsley, T.B., Segers, G., Nuss, D.L., and A.L. Dawe (2003). Analysis of altered G-protein subunit accumulation in Cryphonectria parasitica reveals a third Gα homologue. Current Gentics. 43: 24-33. |
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| Meet ImQuest Life Sciences's Staff at the Following Scientific Meetings: |
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International Conference on Antiviral Research (Palm Springs, CA, May 2007)
American Association of Pharmaceutical Science-Biotechnology (San Diego, CA June 2007)
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DART-HIV (Cancun, Mexico, December 2006) |
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Internscience Conference of Antimicrobial Agents and Chemotherapy (Chicago, September 2007)
DART-HCV (Hawaii, December 2007)
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